Eleven years after the events of the Clerks, Dante Hicks (Brian O'Halloran) opens the Quick Stop convenience store to find that it is on fire; Randal Graves (Jeff Anderson) had left the coffee pot on after closing the night before. As a result of the destruction of Quick Stop and the adjacent RST Video, Dante and Randal begin working at a Mooby the Golden Calf fast food restaurant along with Elias (Trevor Fehrman) and their manager List of View Askewniverse characters#Becky Scott (Rosario Dawson). A year later, Dante is planning to leave his minimum wage lifestyle in favor of a family life in Florida with his fiancée Emma Bunting (Jennifer Schwalbach Smith), whose father will provide them with a home and a business to run. This leaves Randal, who fears that with Dante moving to Florida would leave him without his best friend, bitterly disappointed. Jay and Silent Bob (Jason Mewes and Kevin Smith) have since followed Dante and Randal, and now loiter outside of Mooby's. Jay and Silent Bob no longer do drugs after they were arrested for possession and were sent to Drug rehabilitation, and become devout Christians following their release. However, the duo continue selling drugs.

Seven years after he survived the monster apocalypse, lovably hapless Joel leaves his cozy underground bunker behind on a quest to reunite with his high school sweetheart.

Gloria is an out-of-work party girl forced to leave her life in New York City and move back home. When reports surface that a giant creature is destroying Seoul, she gradually comes to the realization that she is somehow connected to this phenomenon.

In an alternate present-day version of Oakland, telemarketer Cassius Green discovers a magical key to professional success, propelling him into a universe of greed.